Antidiabetic, Thrombolytic, Antimicrobial, Antioxidant and Cytotoxicity Studies of Brinjal (Solanum Melongena) Leaves Extracts

Rabia Saqlain, Muhammad Riaz*, Shabbir Hussain, Muhammad Afzal, Rehman Qadir

  • Muhammad Riaz
Keywords: Solanum melongena, Antioxidant, Antidiabetic, Plant extract, Thrombolytic


ABSTRACT: Phytochemical, antioxidant, cytotoxicity, antimicrobial, and antidiabetic of brinjal (Solanum melongena) leave extracts in the present study. The selected plant material was dipped in different polarity-based solvents for one weak such as chloroform, n-hexane, methanol, ethyl acetate, and n-butanol. By using spectroscopic techniques total phenolic contents (TPC) and total flavonoid contents (TFC) were analyzed. The range of total phenolic contents was 159.48 ± 1.49 to 23.19 ± 0.40 GAE mg/100 g. The range of total flavonoid contents was 4.87± 0.28 to 29.6 ± 0.24 CE mg/100 g. Extracts had an antioxidant activity which was evaluated by using free radical scavenging DPPH assay. Total phenolic contents and the ratio inhibition in linoleic acid oxidation were also calculated. The present study result revealed that the leaves of the Solanum melongena plant may be the main source of natural antioxidants and it is also used as an antidiabetic activity. In the present study, the potential of extracts against the selected bacterias (Bacillus subtilis and Escherichia coli) and fungi (Fusarium solani and Aspergillus nigar) was evaluated. The plant extracts were examined against human red blood cells (RBCs) and the percentage lysis was also found in this research work. Statistical data analysis was done by Analysis of variance (ANOVA) using SPSS version 21.0.