Nature and Effects of Cholesterol; Its Origin, Metabolism and Characterization
Safdar Amir, Shabbir Hussain* and Naureen Naeem
Cholesterol ((3β)-cholest-5-en-3-ol) is basically a fatty component present in blood, plasma and tissues. It belongs to the class of lipids namely steroids and is formed from squalene via lanosterol. It is present as a combination of cholesterol and cholesteryl esters in almost all types of foodstuffs. There is the direct relation between the risk of cardiovascular sicknesses and the total cholesterol amount in human blood. The bad- and good-cholesterol are types of lipoproteins. Good-cholesterol basically eliminates cholesterol from bloodstream while bad-cholesterol releases cholesterol into the blood and various part of body. Cholesterol amount can be reduced by physical activity or by use of proper diet. Cholesterol can be characterized by the SIM-selected ion monitoring, HPLC, UHPLC, GLC, GC-MS, LC-MS.