Antidiabetic, Thrombolytic, Antimicrobial, Antioxidant and Cytotoxicity Studies of Brinjal (Solanum Melongena) Leaves Extracts

Abstract

Phytochemical, antioxidant, cytotoxicity, antimicrobial, and antidiabetic
of brinjal (Solanum melongena) leave extracts in the present study. The selected plant
material was dipped in different polarity-based solvents for one weak such as
chloroform, n-hexane, methanol, ethyl acetate, and n-butanol. By using spectroscopic
techniques total phenolic contents (TPC) and total flavonoid contents (TFC) were
analyzed. The range of total phenolic contents was 159.48 ± 1.49 to 23.19 ± 0.40 GAE
mg/100 g. The range of total flavonoid contents was 4.87± 0.28 to 29.6 ± 0.24 CE
mg/100 g. Extracts had an antioxidant activity which was evaluated by using free
radical scavenging DPPH assay. Total phenolic contents and the ratio inhibition in
linoleic acid oxidation were also calculated. The present study result revealed that the
leaves of the Solanum melongena plant may be the main source of natural antioxidants
and it is also used as an antidiabetic activity. In the present study, the potential of
extracts against the selected bacterias (Bacillus subtilis and Escherichia coli) and
fungi (Fusarium solani and Aspergillus nigar) was evaluated. The plant extracts were
examined against human red blood cells (RBCs) and the percentage lysis was also
found in this research work. Statistical data analysis was done by Analysis of variance
(ANOVA) using SPSS version 21.0.