Ginseng Malva Verticillata Tea (GMVT) Improve Glucose and Lipid Metabolism by Up-regulation of Leptin Hormone in Overweight Rats

Abstract

Hyperglycemia plays a main role in the pathogenesis of cardiovascular
diseases, fatty liver disease and insulin resistance in Diabetes mellitus type 2 (T2DM).
Excess adipose tissue is the main risk factor for developing T2DM. Numerous drugs
have been approved to reduce body weight and these medicines act by increasing
lipolysis, decreasing satiety level, and increasing thermogenesis. But due to their
adverse effects they are withdraw from the market. People are interested in using herbs
and herbal drugs to achieve the best effect with fewer side effects. Traditionally in
Asia, cinnamon (Cinnamomum verum), bitter gourd (Momordica charantia), dill
(Anethum graveolens), black cumin (Nigella sativa). Turmeric, Ginger, green
cardamom, Fenugreek and Ginseng use to improve hyperlipidemic and hypoglycemic
conditions. In the current study, we treated overweight rats to ginseng tea. Results
demonstrated a significant decrease in glucose, LDL-C, and cholesterol while increase
in the HDL-C and leptin levels. Leptin is belonging to cytokine release from adipose
tissue exhibit decrease satiety, increase energy expenditure and reduce fat by inhibiting
lipogenesis and increasing lipolysis. Thus, it was concluded Ginseng Malva
Verticillata tea (GMVT) can be suggested as a possible alternative treatment to
improve lipid profile, hyperglycemia and related pathogeneses