Prevalence and Frequency Distribution of HLA-A, HLA-B and HLA-C Alleles in the Punjab, Pakistan
Saba Sajjad, Imran Tipu, Muhammad Ali, Muhammad Irfan Fareed, Rana Muhammad Kamran Shabbir, Faiza Samrez, Fareeha Ahmed, Wasiq Ikram, Rubina Dad, Mureed Hussain, Rana Muhammad Mateen, Rukhsana Parveen, Muhammad Sohail Afzal
The Human Leukocyte Antigen (HLA) system, a set of highly polymorphic genes, has been found to play an effective role in the disease resistance and disease susceptibility. In this study, prevalence of class-I alleles of HLA was characterized at HLAA,- B and -C loci in the 216 individuals randomly selected population at different regions of Punjab province of Pakistan. The study revealed that at HLA-A locus the allele 11 was most prevalent with 16.7 % frequency. Similarly, at HLA-B locus the allele 51 was found abundant with 15% frequency and at HLA-C locus the allele 7 was prevalent with 24% frequency. Among the two-locus HLA class I haplotypes, B*08/C*07 was found to be the most prevalent followed by B*35/C*04. Surprisingly, HLA-B*29 and HLA-B*36 alleles were found in the Punjabi population which is contrary to the previous reports.