Relationship Analyses of Overweight and Obesity with Liver Function

Saima Sharif, Fizza Tanveer, Shagufta Naz

Abstract

ABSTRACT: Obesity is a treatable medical condition marked by a high accumulation of fats in the body, a result of food intake or lowered bodily exercise. Obesity is one of the widespread causative factors for liver health. The liver performs a central function in carbohydrate, protein, fats metabolism and detoxification. This research aims to examine the impact of overweight and obesity on female liver functions and to exhibit the correlation of BMI with liver enzymes in normal, overweight and obese subjects. In this cross-sectional study, a complete of 75 subjects was enrolled. Sampling was carried out from Lahore College for Women University, Lahore. Liver enzymes Alanine aminotransaminase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) had been analyzed through a chemistry analyzer. The enrolled subjects were classified into three groups based on BMI i.e. Normal weight (n=25), overweight (n=25) and obese (n=25), following the WHO criteria. Correlation analysis of BMI with liver enzymes demonstrated that ALP was positively correlated with BMI in obese (r= 0.328) and overweight (r=0.198) subjects. A significant relationship was observed between ALT and BMI in obese subjects(r=0.467). AST and BMI (r=0.074) showed a direct correlation in overweight subjects. So it was concluded that obese and weight problems significantly affect liver function and may result in further complications of the liver.