Prevalence and Frequency Distribution of HLA-A, HLA-B and HLA-C Alleles in the Punjab, Pakistan

Authors

  • Imran Tipu Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan
  • Saba Sajjad Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan
  • Muhammad Ali Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan
  • Muhammad Irfan Fareed Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan
  • Rana Muhammad Kamran Shabbir Department of Zoology, Division of Science and Technology, University of Education, Lahore.
  • Faiza Samrez Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan
  • Fareeha Ahmed Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan
  • Wasiq Ikram School of Botany, Minhaj University, Lahore
  • Rubina Dad Nature G, co Ltd Tianjin Institute of Industrial Biotechnology, Tianjin China.
  • Mureed Hussain Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan
  • Rana Muhammad Mateen Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan
  • Rukhsana Parveen Centre for Applied Molecular Biology, University of the Punjab, Lahore
  • Muhammad Sohail Afzal Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan

DOI:

https://doi.org/10.54692/lgujls.2023.0702259

Keywords:

Allele frequency, HLA, MHC-I,, Pakistan

Abstract

The Human Leukocyte Antigen (HLA) system, a set of highly polymorphic genes, has been found to play an effective role in the disease resistance and disease susceptibility. In this study, prevalence of class-I alleles of HLA was characterized at HLA A,-B and -C loci in the 216 individuals randomly selected population at different regions of Punjab province of Pakistan. The study revealed that at HLA-A locus the allele 11 was most prevalent with 16.7 % frequency. Similarly, at HLA-B locus the allele 51 was found abundant with 15% frequency and at HLA-C locus the allele 7 was prevalent with 24% frequency. Among the two-locus HLA class I haplotypes, B*08/C*07 was found to be the most prevalent followed by B*35/C*04. Surprisingly, HLA-B*29 and HLA-B*36 alleles were found in the Punjabi population which is contrary to the previous reports.

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Published

2023-06-15

Issue

Vol. 7 No. 02 (2023): LGU Journal of Life Sciences

Section

Articles