Prevalence and Frequency Distribution of HLA-A, HLA-B and HLA-C Alleles in the Punjab, Pakistan

Saba Sajjad, Imran Tipu, Muhammad Ali, Muhammad Irfan Fareed, Rana Muhammad Kamran Shabbir, Faiza Samrez, Fareeha Ahmed, Wasiq Ikram, Rubina Dad, Mureed Hussain, Rana Muhammad Mateen, Rukhsana Parveen, Muhammad Sohail Afzal

  • Saba Sajjad Department of Life Sciences, School of Science, University of Management and Technology, C-II Johar Town, Lahore 54770, Pakistan
  • Imran Tipu Department of Life Sciences, School of Science, University of Management and Technology, Lahore
  • Muhammad Ali Department of Life Sciences, School of Science, University of Management and Technology, Lahore
  • Muhammad Irfan Fareed Department of Life Sciences, School of Science, University of Management and Technology, Lahore
  • Rana Muhammad Kamran Shabbir Department of Zoology, Division of Science and Technology, University of Education, Lahore.
  • Faiza Samrez Department of Life Sciences, School of Science, University of Management and Technology, Lahore
  • Fareeha Ahmed Department of Life Sciences, School of Science, University of Management and Technology, Lahore
  • Wasiq Ikram School of Botany, Minhaj University, Lahore
  • Rubina Dad Nature G, co Ltd Tianjin Institute of Industrial Biotechnology, Tianjin China
  • Mureed Hussain Department of Life Sciences, School of Science, University of Management and Technology, Lahore
  • Rana Muhammad Mateen Department of Life Sciences, School of Science, University of Management and Technology, Lahore
  • Rukhsana Parveen Centre for Applied Molecular Biology, University of the Punjab, Lahore
  • Muhammad Sohail Afzal Department of Life Sciences, School of Science, University of Management and Technology, Lahore
DOI: https://doi.org/10.54692/lgujls.2023.0702259
Keywords: Allele frequency, HLA, MHC-I, Pakistan

Abstract

The Human Leukocyte Antigen (HLA) system, a set of highly polymorphic genes, has been found to play an effective role in the disease resistance and disease susceptibility. In this study, prevalence of class-I alleles of HLA was characterized at HLAA,- B and -C loci in the 216 individuals randomly selected population at different regions of Punjab province of Pakistan. The study revealed that at HLA-A locus the allele 11 was most prevalent with 16.7 % frequency. Similarly, at HLA-B locus the allele 51 was found abundant with 15% frequency and at HLA-C locus the allele 7 was prevalent with 24% frequency. Among the two-locus HLA class I haplotypes, B*08/C*07 was found to be the most prevalent followed by B*35/C*04. Surprisingly, HLA-B*29 and HLA-B*36 alleles were found in the Punjabi population which is contrary to the previous reports.

Published
2023-06-26
Issue
Vol. 7 No. 02 (2023): LGU Journal of Life Sciences
Section
Articles